How much does the hand-holdedness (yes, it's a word, it's a neologism) show? A lot. And it is awesome. All of the takes are amazingly long. The cinematography, with one or two minor exceptions, is PERFECT.
Your B point isn't known in the movie. No one knows why women are infertile, and that's an important part of the movie (the ignorance and fear).
Just see the movie, though. It's not really possible to discuss it with someone who hasn't seen it.